Woo Seul Ki grew up in an orphanage out in a province. She moves to Seoul and enrolls in Chaehwa High School, which is a school for the top 1% students in South Korea. Woo Seul Ki doesn't get along with the other students. A student named Yoo Je Yi approaches her and they become friends.

Park Seong A is a high school student, but, at night, she is a shaman named Fairy Cheon Ji. When she works as a shaman, she covers her face partially to hide her identity.

Hospital Playlist tells the story of five doctors who have been friends since they entered medical school in 1999.